In vitro biological properties and health benefits of a novel sulfated polysaccharide isolated from Cymodocea nodosa

Abstract

Background: During the last few decades, there has been a growing interest in the search for novel bioactive compounds from marine origins.

Methods: The present study is the first to determine the molecular characterization which it was deposited in the genebank database, to investigate and evaluate the biological properties of sulfated polysaccharide from Cymodocea nodosa (CNSP) seagrass.

Results: The results revealed that CNSP had high activity in total antioxidant assay (59.03 mg ascorbic acid equivalents/g extract), reducing power (OD = 0.3), DPPH radical scavenging (IC₅₀ = 1.22 mg/ml) and ABTS radical scavenging (IC₅₀ = 1.14 mg/ml). It was also noted to exhibit antimicrobial activity against a wide range of microorganisms, with important inhibition zones. The results revealed that CNSP was able to inhibit the proliferation of Hela cell lines with a dose-dependent manner.

Conclusion: Overall, the results presented in this study demonstrate that CNSP has several attractive antioxidant, antimicrobial and antiproliferative properties with potential benefits towards health.

Keywords: Antimicrobial; Antioxidant; Cytotoxicity test; DNA; GCMS; PCR; Polysaccharide.