Meiosis: The Origins of Bias

Taekyung Kim; Arshad Desai

doi:10.1016/j.cub.2017.10.055

Meiosis: The Origins of Bias

Curr Biol. 2017 Dec 18;27(24):R1309-R1311. doi: 10.1016/j.cub.2017.10.055.

Authors

Taekyung Kim¹, Arshad Desai²

Affiliations

¹ Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA; Department of Cellular & Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA.
² Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA; Department of Cellular & Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: abdesai@ucsd.edu.

Abstract

Biased, or non-Mendelian, segregation is frequently observed but not well understood. Two recent studies on a specific type of biased segregation in mammalian meiosis suggest that it arises from centromeric satellite expansion and asymmetric modification of microtubules in the oocyte spindle.

Publication types

Comment

MeSH terms

Animals
Female
Meiosis
Microtubules
Nucleosomes*
Oocytes
Spindle Apparatus / genetics*

Substances

Nucleosomes

Grants and funding

R01 GM074215/GM/NIGMS NIH HHS/United States