[Microdeletion and Mutation of Y Chromosome in Full Sibling Identification]

Fa Yi Xue Za Zhi. 2016 Dec;32(6):438-440. doi: 10.3969/j.issn.1004-5619.2016.06.011. Epub 2016 Dec 25.
[Article in Chinese]

Abstract

Objectives: To explore the identification method of full sibling between two males with microdeletion and mutation of Y chromosome.

Methods: DNA were extracted from two samples. The type testing of Y-STR and autosomal STR were performed. Full sibling between two individuals was calculated by IBS, ITO and discriminant functions methods.

Results: There were 2 loci mutations existed in 33 Y-STR loci and one of the two samples had 19 loci deletions. The IBS of two samples was 53 and greater than the threshold which was 42; FSI was 1.36×10¹⁶ and far greater than 19. The discriminant function of full sibling-unrelated individual DFS2 was greater than DR2, which meant the two individuals tend to be full sibling.

Conclusions: The methods of IBS, ITO and discriminant functions of full sibling-unrelated individual can be used comprehensively to provide more reliable expert opinion in microdeletion and mutation of Y chromosome in full sibling identification.

Keywords: Y chromosome; chromosome deletion; forensic genetics; mutation; sibling relations.

MeSH terms

  • Alleles
  • Chromosome Aberrations*
  • Chromosomes, Human, Y / genetics*
  • Discriminant Analysis
  • Forensic Genetics*
  • Humans
  • Male
  • Polymerase Chain Reaction
  • Sequence Deletion*
  • Siblings