Scabies in the age of increasing drug resistance

Samar Khalil; Ossama Abbas; Abdul Ghani Kibbi; Mazen Kurban

doi:10.1371/journal.pntd.0005920

Scabies in the age of increasing drug resistance

PLoS Negl Trop Dis. 2017 Nov 30;11(11):e0005920. doi: 10.1371/journal.pntd.0005920. eCollection 2017 Nov.

Authors

Samar Khalil¹, Ossama Abbas¹, Abdul Ghani Kibbi¹, Mazen Kurban^{1

2

3}

Affiliations

¹ Department of Dermatology, American University of Beirut, Beirut, Lebanon.
² Department of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon.
³ Department of Dermatology, Columbia University Medical Center, New York, New York, United States of America.

Abstract

Scabies is an infestation of the skin by the mite Sarcoptes scabiei. It manifests with pruritic erythematous papules and excoriations, in addition to the pathognomonic burrows. Multiple drugs can be used for treatment, but resistance to conventional therapy is increasing throughout the years. This paper will review the mechanisms of resistance proposed in the literature and some of the potential solutions to this problem.

Publication types

Review

MeSH terms

ATP-Binding Cassette Transporters / metabolism
Animals
Humans
Insecticide Resistance*
Insecticides / therapeutic use
Sarcoptes scabiei / drug effects*
Scabies / complications
Scabies / drug therapy*
Scabies / parasitology
Skin / parasitology
Sodium Channels / metabolism

Substances

ATP-Binding Cassette Transporters
Insecticides
Sodium Channels

Grants and funding

The authors received no specific funding for this work.