Constraining the Teratogenicity of Pesticide Pollution by a Synthetic Nanoreceptor

Chem Asian J. 2018 Jan 4;13(1):41-45. doi: 10.1002/asia.201701527. Epub 2017 Dec 6.

Abstract

The teratogenicity of the pesticide nereistoxin (NTX) and its derivative thiocyclam (THI) towards aquatic life was dramatically constrained by a synthetic nanoreceptor, cucurbit[7]uril, through selective encapsulation of the pesticides (KCB[7]-NTX of 3.24(±0.31)×106 m-1 and KCB[7]-THI of 7.46(±0.10)×105 m-1 ), as evidenced by the rate of hatchability, morphology development, and tyrosinase activity of zebrafish larvae incubated with the pesticides (3-300 μm) in the absence and in the presence of 300 μm cucurbit[7]uril, demonstrating the significant potential of the nanoreceptor in managing ecological pollution of these pesticides.

Keywords: cucurbit[7]uril; pesticide pollution; synthetic nanoreceptors; teratogenicity; zebrafish.

MeSH terms

  • Animals
  • Bridged-Ring Compounds / chemistry
  • Bridged-Ring Compounds / pharmacology*
  • Dose-Response Relationship, Drug
  • Heterocyclic Compounds, 1-Ring / antagonists & inhibitors*
  • Heterocyclic Compounds, 1-Ring / chemistry
  • Heterocyclic Compounds, 1-Ring / toxicity*
  • Imidazoles / chemistry
  • Imidazoles / pharmacology*
  • Larva / drug effects
  • Marine Toxins / antagonists & inhibitors*
  • Marine Toxins / chemistry
  • Marine Toxins / toxicity*
  • Molecular Structure
  • Structure-Activity Relationship
  • Teratogens / chemistry
  • Teratogens / toxicity*
  • Water Pollutants, Chemical / antagonists & inhibitors*
  • Water Pollutants, Chemical / chemistry
  • Water Pollutants, Chemical / toxicity
  • Zebrafish

Substances

  • Bridged-Ring Compounds
  • Heterocyclic Compounds, 1-Ring
  • Imidazoles
  • Marine Toxins
  • N,N-dimethyl-1,2,3-trithian-5-yl amine
  • Teratogens
  • Water Pollutants, Chemical
  • cucurbit(7)uril
  • nereistoxin