Single nucleotide polymorphisms in TNF are associated with susceptibility to aspirin-exacerbated respiratory disease but not to cytokine levels: a study in Mexican mestizo population

Biomark Med. 2017 Dec;11(12):1047-1055. doi: 10.2217/bmm-2017-0164. Epub 2017 Nov 27.

Abstract

Aim: To evaluate the association of three single nucleotide polymorphisms in TNF and one in LTA in Mexican patients with aspirin-exacerbated respiratory disease (AERD) and the correlation of those single nucleotide polymorphisms with serum levels of TNF-α.

Patients & methods: Case-control study including 133 patients with AERD, 135 patients with asthma (aspirin-tolerant asthmatics) and 182 healthy subjects.

Results: GA genotype of rs1800629 in TNF was found to be associated with the risk of developing AERD (p < 0.05; odds ratio = 2.36) and by dominant model (p < 0.05; odds ratio = 2.51). Furthermore, there was a difference in the serum levels between the aspirin-tolerant asthmatics group and the other groups (p < 0.001).

Conclusion: The GA genotype of rs1800629 is associated with genetic susceptibility to AERD, but it does not correlate to protein serum levels.

Keywords: AERD; TNF; aspirin; asthma; genetic susceptibility.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Asthma, Aspirin-Induced / epidemiology
  • Asthma, Aspirin-Induced / ethnology
  • Asthma, Aspirin-Induced / genetics*
  • Case-Control Studies
  • Female
  • Genetic Predisposition to Disease*
  • Genotype*
  • Humans
  • Male
  • Mexico / epidemiology
  • Mexico / ethnology
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Tumor Necrosis Factor-alpha / genetics*

Substances

  • Tumor Necrosis Factor-alpha