Keywords: KLK5, kallikrein 5; NS, Netherton syndrome; Netherton syndrome; PAR2, protease-activated receptor 2; SPINK5, serine protease inhibitor Kazal type 5; TNF, tumor necrosis factor; TSLP, thymic stromal lymphopoietin; Th, helper T cell; ichthyosis; infliximab; tumor necrosis factor-α.