Obesity as a Disease

Jagriti Upadhyay; Olivia Farr; Nikolaos Perakakis; Wael Ghaly; Christos Mantzoros

doi:10.1016/j.mcna.2017.08.004

Obesity as a Disease

Med Clin North Am. 2018 Jan;102(1):13-33. doi: 10.1016/j.mcna.2017.08.004. Epub 2017 Oct 21.

Authors

Jagriti Upadhyay¹, Olivia Farr², Nikolaos Perakakis², Wael Ghaly², Christos Mantzoros³

Affiliations

¹ Section of Endocrinology, Diabetes and Metabolism, Boston VA Healthcare System, 150 South Huntington Avenue, Boston, MA 02130, USA; Division of Endocrinology, Boston Medical Center, Boston University, 88 East Newton Street, Boston, MA 02118; Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA. Electronic address: jupadhya@bidmc.harvard.edu.
² Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
³ Section of Endocrinology, Diabetes and Metabolism, Boston VA Healthcare System, 150 South Huntington Avenue, Boston, MA 02130, USA; Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

PMID: 29156181
DOI: 10.1016/j.mcna.2017.08.004

Abstract

Obesity is a complex disease with many causal factors, associated with multiple comorbidities that contribute to significant morbidity and mortality. It is a highly prevalent disease that poses an enormous health and economic burden to society. This article reviews the mechanisms of obesity and its related comorbidities.

Keywords: Cardiovascular disease and metabolic syndrome; Causes and mechanism; Metabolically healthy; Obesity.

Publication types

Review

MeSH terms

Comorbidity
Cost of Illness
Diabetes Mellitus, Type 2 / epidemiology
Health Status*
Humans
Metabolic Diseases / epidemiology
Obesity / economics
Obesity / epidemiology*
Prevalence
Primary Prevention / organization & administration*
Risk Factors