Serum CCL20 and its association with SIRT1 activity in multiple sclerosis patients

Rui Li; Xiaobo Sun; Yaqing Shu; Yuge Wang; Li Xiao; Zhanhang Wang; Xueqiang Hu; Allan G Kermode; Wei Qiu

doi:10.1016/j.jneuroim.2017.10.013

Serum CCL20 and its association with SIRT1 activity in multiple sclerosis patients

J Neuroimmunol. 2017 Dec 15:313:56-60. doi: 10.1016/j.jneuroim.2017.10.013. Epub 2017 Oct 19.

Authors

Rui Li¹, Xiaobo Sun¹, Yaqing Shu¹, Yuge Wang¹, Li Xiao¹, Zhanhang Wang², Xueqiang Hu¹, Allan G Kermode³, Wei Qiu⁴

Affiliations

¹ Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province, China.
² Department of Neurology, Guangdong 999 Brain Hospital, China.
³ Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province, China; Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Department of Neurology, Sir Charles Gairdner Hospital, Queen Elizabeth II Medical Centre, Perth, Australia; Institute of Immunology and Infectious Diseases, Murdoch University, Perth, Australia.
⁴ Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province, China. Electronic address: qw9406@gmail.com.

PMID: 29153609
DOI: 10.1016/j.jneuroim.2017.10.013

Abstract

CCL20 is a potentially important component in the pathogenesis of multiple sclerosis (MS). SIRT1 exhibits a negative regulatory effect on a variety of inflammatory cytokines and can relieve experimental autoimmune encephalomyelitis. The association between the level of CCL20 and SIRT1 activity in MS patients has not been investigated. In the present study, blood samples were collected from 38 RRMS patients and 40 healthy controls. The serum CCL20 levels were measured by ELISA. SIRT1 activity was evaluated by fluorometric assay. We revealed elevated serum CCL20 concentrations in MS, and discovered an inverse correlation between CCL20 and SIRT1 activity in MS patients.

Keywords: CCL20; Multiple sclerosis; SIRT1.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Chemokine CCL20 / blood*
Disability Evaluation
Female
Histone Deacetylases / metabolism
Humans
Magnetic Resonance Imaging
Male
Multiple Sclerosis, Relapsing-Remitting / blood*
Multiple Sclerosis, Relapsing-Remitting / diagnostic imaging
Regression Analysis
Sirtuin 1 / blood*

Substances

CCL20 protein, human
Chemokine CCL20
SIRT1 protein, human
Sirtuin 1
Histone Deacetylases