Metagenomic analysis identified co-infection with human rhinovirus C and bocavirus 1 in an adult suffering from severe pneumonia

J Infect. 2018 Mar;76(3):311-313. doi: 10.1016/j.jinf.2017.10.012. Epub 2017 Oct 31.

¹ The Joint Center for Infection and Immunity, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China; The Joint Center for Infection and Immunity, Institute Pasteur of Shanghai, Chinese Academy of Science, Shanghai 200031, China; Pathogen Diagnostic Center, CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Science, Shanghai 200031, China.
² Institute of Infectious disease, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510060, China.
³ BGI-Shenzhen, Shenzhen 518083, China.
⁴ The Joint Center for Infection and Immunity, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China.
⁵ Institute of Infectious disease, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510060, China. Electronic address: gz8hzfc@126.com.
⁶ The Joint Center for Infection and Immunity, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China; The Joint Center for Infection and Immunity, Institute Pasteur of Shanghai, Chinese Academy of Science, Shanghai 200031, China; Pathogen Diagnostic Center, CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Science, Shanghai 200031, China. Electronic address: zhangcy1999@ips.ac.cn.

Abstract

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We first present a HRV-C and HBoV1 co-infection in an adult woman with severe acute respiratory distress syndrome.
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Our study suggests that HBoV1 co-infection might worsen the disease caused by HRV-C infection, and raises a question whether HRV-C-related severe pneumonia is often associated with co-infection of other respiratory viruses such as bocavirus.