Abnormal Resting-State Functional Connectivity of Insular Subregions and Disrupted Correlation with Working Memory in Adults with Attention Deficit/Hyperactivity Disorder

Qihua Zhao; Hui Li; Xiaoyan Yu; Fang Huang; Yanfei Wang; Lu Liu; Qingjiu Cao; Qiujin Qian; Yufeng Zang; Li Sun; Yufeng Wang

doi:10.3389/fpsyt.2017.00200

Abnormal Resting-State Functional Connectivity of Insular Subregions and Disrupted Correlation with Working Memory in Adults with Attention Deficit/Hyperactivity Disorder

Front Psychiatry. 2017 Oct 11:8:200. doi: 10.3389/fpsyt.2017.00200. eCollection 2017.

Authors

Qihua Zhao^{1

2}, Hui Li^{1

2}, Xiaoyan Yu^{1

2}, Fang Huang^{1

2}, Yanfei Wang^{1

2}, Lu Liu^{1

2}, Qingjiu Cao^{1

2}, Qiujin Qian^{1

2}, Yufeng Zang^{3

4}, Li Sun^{1

2}, Yufeng Wang^{1

2}

Affiliations

¹ Peking University Sixth Hospital, Institute of Mental Health, Beijing, China.
² National Clinical Research Center for Mental Disorders, Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing, China.
³ Center for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, China.
⁴ Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, China.

Abstract

Objectives: Executive function (EF) deficits are major impairments in adults with attention deficit/hyperactivity disorder (ADHD). Previous studies have shown that the insula is involved in cognitive and EFs. However, the insula is highly heterogeneous in function, and few studies have focused on functional networks which related to specific insular subregions in adults with ADHD. We explored the functional networks of the insular subregions [anterior insula (AI), mid-insula (MI), and posterior insula (PI)]. Furthermore, their correlations with self-ratings of ecological EFs, including inhibition, shifting, and working memory were investigated.

Methods: Resting-state functional magnetic resonance imaging data in 28 adults with ADHD and 30 matched healthy controls (HCs) were analyzed. The seed-based resting-state functional connectivity (RSFC) of the insular subregions was evaluated. We also investigated their associations with the Behavior Rating Inventory of Executive Function-Adult Version (BRIEF-A) inhibition, working memory, and shifting factor scores.

Results: Compared with HCs, adults with ADHD showed altered RSFC of the AI, with the precuneus, precentral gyrus, and inferior temporal gyrus extended to the middle temporal gyrus, lingual gyrus, and superior occipital gyrus, respectively. There were no significant differences in RSFC of the MI and PI between the two groups. Within the HC group, working memory scores were associated with the RSFC of AI with precuneus and temporal gyrus. However, there was no correlation between these variables in the ADHD group.

Conclusion: The study evaluated RSFC patterns of the insular subregions in adults with ADHD for the first time. Altered RSFC of the AI which is a crucial region of salience network (SN) and part of regions in default mode network (DMN), were detected in adults with ADHD in both results with and without global signal regression (GSR), suggesting that disrupted SN-DMN functional connectivity may be involved in EF impairments in adults with ADHD, especially with respect to working memory. Deficits of the AI which is involved in salient stimuli allocation, might be associated with the pathophysiology of ADHD. The inconsistent results of MI and PI between analyses with and without GSR need further exploration.

Keywords: attention deficit/hyperactivity disorder; default mode network; executive function; insular subregions; resting-state functional connectivity; salience network.