Improved Spatiotemporal Resolution of Dynamic Susceptibility Contrast Perfusion MRI in Brain Tumors Using Simultaneous Multi-Slice Echo-Planar Imaging

A Chakhoyan; K Leu; W B Pope; T F Cloughesy; B M Ellingson

doi:10.3174/ajnr.A5433

Improved Spatiotemporal Resolution of Dynamic Susceptibility Contrast Perfusion MRI in Brain Tumors Using Simultaneous Multi-Slice Echo-Planar Imaging

AJNR Am J Neuroradiol. 2018 Jan;39(1):43-45. doi: 10.3174/ajnr.A5433. Epub 2017 Oct 26.

Authors

A Chakhoyan^{1

2}, K Leu^{1

2

3}, W B Pope², T F Cloughesy^{4

5

6}, B M Ellingson^{7

2

8

9

4

3

6}

Affiliations

¹ From the UCLA Brain Tumor Imaging Laboratory (A.C., K.L., B.M.E.), Center for Computer Vision and Imaging Biomarkers, University of California, Los Angeles, Los Angeles, California.
² Departments of Radiological Sciences (A.C., K.L., W.B.P., B.M.E.).
³ Department of Bioengineering (K.L., B.M.E.), Henry Samueli School of Engineering and Applied Science.
⁴ UCLA Brain Research Institute (T.F.C., B.M.E.).
⁵ Neurology (T.F.C.), David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
⁶ UCLA Neuro-Oncology Program (T.F.C., B.M.E.), University of California, Los Angeles, Los Angeles, California.
⁷ From the UCLA Brain Tumor Imaging Laboratory (A.C., K.L., B.M.E.), Center for Computer Vision and Imaging Biomarkers, University of California, Los Angeles, Los Angeles, California bellingson@mednet.ucla.edu.
⁸ Biomedical Physics (B.M.E.).
⁹ Psychiatry and Biobehavioral Sciences (B.M.E.).

Abstract

DSC perfusion MR imaging in brain tumors requires a trade-off between spatial and temporal resolution, resulting in less spatial coverage to meet the temporal resolution requirements for accurate relative CBV estimation. DSC-MR imaging could potentially benefit from the advantages associated with simultaneous multi-slice imaging, including increased spatiotemporal resolution. In the current article, we demonstrate how simultaneous multi-slice EPI can be used to improve DSC-MR imaging spatiotemporal resolution in patients with glioblastoma.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Brain Neoplasms / diagnostic imaging*
Brain Neoplasms / pathology
Echo-Planar Imaging / methods*
Glioblastoma / diagnostic imaging*
Glioblastoma / pathology
Humans
Image Interpretation, Computer-Assisted / methods*
Male
Perfusion Imaging / methods

Abstract

Publication types

MeSH terms

Grants and funding