A Search for Dual Action HIV-1 Reverse Transcriptase, Bacterial RNA Polymerase Inhibitors

Molecules. 2017 Oct 25;22(11):1808. doi: 10.3390/molecules22111808.

Abstract

Using molecular modeling approach, potential antibacterial agents with triazole core were proposed. A moderate to weak level of antibacterial activity in most of the compounds have been observed, with best minimal inhibitory concentration (MIC) value of 0.003 mg/mL, as shown by the 15 against S. epidermidis. Studied compounds were also submitted to the antifungal assay. The best antifungal activity was detected for 16 with MIC at 0.125 and 0.25 mg/mL against C. albicans and C. parapsilosis, respectively.

Keywords: antibacterial activity; molecular modeling; triazoles.

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Anti-Retroviral Agents / chemistry
  • Anti-Retroviral Agents / pharmacology
  • Antifungal Agents / chemistry
  • Antifungal Agents / pharmacology
  • Bacterial Proteins / antagonists & inhibitors
  • Candida albicans / drug effects
  • Candida parapsilosis / drug effects
  • DNA-Directed RNA Polymerases / antagonists & inhibitors*
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / pharmacology*
  • HIV Reverse Transcriptase / antagonists & inhibitors*
  • Microbial Sensitivity Tests
  • Models, Molecular
  • Molecular Docking Simulation
  • Molecular Structure
  • Staphylococcus epidermidis / drug effects
  • Structure-Activity Relationship
  • Triazoles / chemistry*
  • Triazoles / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Anti-Retroviral Agents
  • Antifungal Agents
  • Bacterial Proteins
  • Enzyme Inhibitors
  • Triazoles
  • HIV Reverse Transcriptase
  • DNA-Directed RNA Polymerases