Histone deacetylase inhibitor stimulates E2 and P4 secretion in sika deer ovarian granulosa cells at a moderate dose

Cell Biol Int. 2018 Mar;42(3):324-333. doi: 10.1002/cbin.10899. Epub 2018 Jan 22.

Abstract

The histone deacetylase inhibitor (HDACi) and tumor suppressor play an important role in genome reorganization and epigenetic regulation. In this study, granulosa cells (GCs) isolated from sika deer ovaries were cultured and treated with different concentrations of trichostatin A (TSA) for 48 h. It was found that TSA inhibited GCs proliferation and induced GCs apoptosis by upregulating expression of BAX, meanwhile, downregulating expression of GLUT3, GLUT8, BCL-XL. In addition, TSA caused cell cycle arrest at the G1 and G2/M phase accompanied by reducing expression of Cyclin D2 and CDK4. TSA pretreatment increased DNMT3a, DNMT1, HDAC1, and HAT1 expression, and attenuated them when TAS higher than 50 nM. The protein levels of H3K9ac and H4K8ac in GCs were increased at 48 h after TSA treatment. TSA stimulated the secretion of estradiol and progesterone at a moderate dose. Our data suggest that TSA is important as a regulator of steroid hormone synthesis in granulosa cells during follicular development in the sika deer ovary.

Keywords: TSA; apoptosis; cell cycle; granulosa cells; histone acetylation.

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Cell Cycle Checkpoints / drug effects
  • Cell Proliferation / drug effects
  • Deer
  • Estradiol / metabolism*
  • Female
  • G2 Phase / drug effects
  • Granulosa Cells / drug effects*
  • Granulosa Cells / metabolism*
  • Histone Deacetylase Inhibitors / pharmacology*
  • Histone Deacetylases / metabolism
  • Histones / metabolism
  • Hydroxamic Acids / pharmacology*
  • Ovary / cytology
  • Ovary / drug effects
  • Ovary / metabolism
  • Primary Cell Culture
  • Progesterone / metabolism*
  • bcl-2-Associated X Protein / metabolism

Substances

  • Histone Deacetylase Inhibitors
  • Histones
  • Hydroxamic Acids
  • bcl-2-Associated X Protein
  • trichostatin A
  • Progesterone
  • Estradiol
  • Histone Deacetylases