Cytotoxic Half-Sandwich Rh(III) and Ir(III) β-Diketonates

Agnese Petrini; Riccardo Pettinari; Fabio Marchetti; Claudio Pettinari; Bruno Therrien; Agustı N Galindo; Rosario Scopelliti; Tina Riedel; Paul J Dyson

doi:10.1021/acs.inorgchem.7b02356

Cytotoxic Half-Sandwich Rh(III) and Ir(III) β-Diketonates

Inorg Chem. 2017 Nov 6;56(21):13600-13612. doi: 10.1021/acs.inorgchem.7b02356.

Authors

Agnese Petrini, Riccardo Pettinari, Fabio Marchetti, Claudio Pettinari, Bruno Therrien¹, Agustı N Galindo², Rosario Scopelliti³, Tina Riedel³, Paul J Dyson³

Affiliations

¹ Institute of Chemistry, University of Neuchatel , Avenue de Bellevaux 51, CH-2000 Neuchatel, Switzerland.
² Departamento de Química Inorgánica, Facultad de Química, Universidad de Sevilla , Aptdo 1203, 41071 Sevilla, Spain.
³ Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL) , 1015 Lausanne, Switzerland.

PMID: 29053264
DOI: 10.1021/acs.inorgchem.7b02356

Abstract

A series of half-sandwich pentamethylcyclopentadienyl rhodium(III) and iridium(III) complexes [Cp*M(DBM/HDB/AVB)Cl] and [Cp*M(DBM/HDB/AVB)(PTA)][SO₃CF₃], where Cp* = pentamethylcyclopentadienyl, the proligands DBMH = dibenzoylmethane, HDBH = o-hydroxydibenzoylmethane, AVBH = avobenzone, and PTA = 1,3,5-triaza-7-phosphaadamantane, is reported. All the complexes were characterized by IR, ¹H and ¹³C NMR spectroscopy, electrospray ionization mass spectrometry, elemental analysis, and DFT calculations. Five of the complexes have also been characterized in the solid-state by X-ray crystallography. The cytotoxicity of the complexes has been evaluated against human ovarian A2780 and A2780cisR cell lines and, with the only exception of complexes 1 and 2 that display a negligible cytotoxicity, exhibit moderate cytotoxicity toward both cancer cell lines. However, the complexes do not show cancer cell selectivity with respect to human embryonic kidney HEK293 cells.