Relative value of three whole-body MR approaches for PET-MR, including gadofosveset-enhanced MR, in comparison to PET-CT

Clin Imaging. 2018 Mar-Apr:48:62-68. doi: 10.1016/j.clinimag.2017.09.016. Epub 2017 Sep 29.

Abstract

Purpose: Evaluate MR protocol for PET-MR including coronal DWI (cDWI), fat-suppressed T2 (T2w), and gadofosveset-enhanced T1 (CE).

Materials and methods: 18 patients underwent same-day PET-CT and PET-MR. Image quality and performance of each sequence, and combination of all three sequences, was evaluated with respect to PET-CT.

Results: Lesion conspicuity was best on cDWI, while delineation was best on CE. Considering all three sequences combined, both readers showed good sensitivity and specificity (>80%). Relative sensitivity was highest on CE and lowest on T2w.

Conclusions: Whole-body MR performed well in detecting malignant lesions compared to PET-CT. CE showed overall highest performance.

Keywords: DWI; Pet-MR; Whole-body MRI.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Contrast Media
  • Diffusion Magnetic Resonance Imaging / methods
  • Female
  • Gadolinium
  • Humans
  • Image Enhancement / methods
  • Magnetic Resonance Imaging / methods*
  • Male
  • Middle Aged
  • Multimodal Imaging / methods*
  • Neoplasms / diagnosis
  • Neoplasms / diagnostic imaging
  • Neoplasms / pathology*
  • Organometallic Compounds
  • Positron Emission Tomography Computed Tomography / methods*
  • Positron-Emission Tomography / methods
  • Sensitivity and Specificity
  • Tomography, X-Ray Computed / methods
  • Whole Body Imaging / methods*

Substances

  • Contrast Media
  • Organometallic Compounds
  • Gadolinium
  • gadofosveset trisodium