Premature coronary artery disease and early stage chronic kidney disease

QJM. 2018 Oct 1;111(10):683-686. doi: 10.1093/qjmed/hcx179.

Abstract

A 30 year old asymptomatic male with stage 3 chronic kidney disease (CKD) secondary to Focal Segmental Glomerulosclerosis was found to have features of CKD associated cardiomyopathy including left ventricular hypertrophy (LVH) and focal sub-endocardial scarring on cardiac magnetic resonance imaging. There was also a significantly raised CT coronary calcium score and evidence of non-flow limiting coronary artery disease (CAD) on a CT coronary angiogram. Early stage CKD is a major risk factor for cardiovascular risk causing myocardial hypertrophy and fibrosis and coronary artery atheroma. Cardiovascular risk begins to increase from an eGFR of around 75ml/min/1.73m2. The pathophysiology of cardiovascular disease in CKD is under investigation but to date, treatment options are limited. Blood pressure control and statins have the strongest supportive evidence.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Coronary Angiography / adverse effects
  • Coronary Artery Disease / diagnostic imaging*
  • Coronary Artery Disease / etiology
  • Fibrosis
  • Glomerular Filtration Rate
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Renal Insufficiency, Chronic / complications*
  • Renal Insufficiency, Chronic / pathology
  • Risk Factors