Spread of multidrug-resistant high-risk Klebsiella pneumoniae clones in a tertiary hospital from southern Brazil

Infect Genet Evol. 2017 Dec:56:1-7. doi: 10.1016/j.meegid.2017.10.011. Epub 2017 Oct 10.

Abstract

Klebsiella pneumoniae is among the most important pathogens found in hospitals. The emergence of multiple antibiotic resistant K. pneumoniae associated with its virulence factors is a worldwide concern and its early identification is crucial, especially for controlling the spread of emerging clones. This article reports a high prevalence of multiresistant K. pneumoniae in a university hospital in southern Brazil, harboring several virulence and β-lactamase encoding genes, including pandrug-resistant high-risk international clones belonging to the clonal group 258 (ST11, ST15, ST101, ST258, ST340 and ST874).

Keywords: Clonal group 258; K. pneumoniae; MLST; Pandrug-resistance, virulence genes; β-Lactamases.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Brazil / epidemiology
  • Cross Infection*
  • Drug Resistance, Multiple, Bacterial*
  • Humans
  • Klebsiella Infections / epidemiology*
  • Klebsiella Infections / microbiology*
  • Klebsiella pneumoniae / classification
  • Klebsiella pneumoniae / drug effects*
  • Klebsiella pneumoniae / genetics
  • Microbial Sensitivity Tests
  • Multilocus Sequence Typing
  • Phylogeny
  • Tertiary Care Centers*
  • Virulence / genetics
  • Virulence Factors / genetics
  • beta-Lactamases / genetics

Substances

  • Anti-Bacterial Agents
  • Virulence Factors
  • beta-Lactamases