Antimicrobial Resistance Gene Acquisition and Depletion Following Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection

Victor Leung; Caroline Vincent; Thaddeus J Edens; Mark Miller; Amee R Manges

doi:10.1093/cid/cix821

Antimicrobial Resistance Gene Acquisition and Depletion Following Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection

Clin Infect Dis. 2018 Jan 18;66(3):456-457. doi: 10.1093/cid/cix821.

Authors

Victor Leung¹, Caroline Vincent², Thaddeus J Edens³, Mark Miller⁴, Amee R Manges^{5

6}

Affiliations

¹ Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver.
² Department of Microbiology and Immunology, McGill University, Montréal, Québec.
³ Devil's Staircase Consulting, West Vancouver, British Columbia.
⁴ McGill University, Montréal, Québec.
⁵ School of Population and Public Health, University of British Columbia.
⁶ Centre for Disease Control, Vancouver, Canada.

Abstract

Fecal microbiota transplantation (FMT) may be a novel approach to eliminate multidrug-resistant bacteria from the gut and to prevent future infections. Using whole metagenome sequencing data from 8 FMT donor-recipient pairs, we identified 37 and 95 antimicrobial resistance genes that were acquired by or removed from FMT recipients, respectively.

Keywords: Clostridium difficile infection; antimicrobial resistance; fecal microbiota transplantation; metagenomics; multidrug resistance.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology
Clostridium Infections / therapy*
Drug Resistance, Multiple, Bacterial / genetics*
Fecal Microbiota Transplantation / adverse effects*
Feces / microbiology
Gastrointestinal Microbiome*
Genes, Bacterial
Genes, MDR*
High-Throughput Nucleotide Sequencing
Humans
Recurrence

Substances

Anti-Bacterial Agents