Apoptosis, Up the Ante

Palaniraja Thandapani; Iannis Aifantis

doi:10.1016/j.ccell.2017.09.009

Apoptosis, Up the Ante

Cancer Cell. 2017 Oct 9;32(4):402-403. doi: 10.1016/j.ccell.2017.09.009.

Authors

Palaniraja Thandapani¹, Iannis Aifantis²

Affiliations

¹ Department of Pathology, Laura & Isaac Perlmutter Cancer Center, NYU School of Medicine, New York, NY 10016, USA.
² Department of Pathology, Laura & Isaac Perlmutter Cancer Center, NYU School of Medicine, New York, NY 10016, USA. Electronic address: iannis.aifantis@nyumc.org.

PMID: 29017053
DOI: 10.1016/j.ccell.2017.09.009

Abstract

The clinical success of the BH3-mimetic venetoclax has generated increasing interest to target BCL2 family proteins in oncology. In this issue of Cancer Cell, Reyna and colleagues demonstrate the potential of a pharmacological activator of the pro-apoptotic protein BAX to suppress acute myeloid leukemia both alone and together with venetoclax.

Publication types

Comment

MeSH terms

Apoptosis*
Humans
Leukemia, Myeloid, Acute*
Proto-Oncogene Proteins c-bcl-2
bcl-2-Associated X Protein

Substances

Proto-Oncogene Proteins c-bcl-2
bcl-2-Associated X Protein