Abstract
The pyrazole nucleus is an aromatic azole heterocycle with two adjacent nitrogen atoms. Pyrazole derivatives have exhibited a broad spectrum of biological activities, and approved pyrazole-containing drugs include celecoxib, antipyrine, phenylbutazone, rimonabant, and dipyrone. Many research groups have synthesized and evaluated pyrazoles against several biological agents. This review examines recent publications relating the structures of pyrazoles with their corresponding biological activities.
Copyright © 2017 Elsevier Ltd. All rights reserved.
Publication types
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Review
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Research Support, Non-U.S. Gov't
MeSH terms
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Analgesics / chemistry
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Analgesics / pharmacology
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology
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Humans
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Pyrazoles / chemistry
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Pyrazoles / pharmacology*
Substances
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Analgesics
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Anti-Bacterial Agents
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Anti-Inflammatory Agents, Non-Steroidal
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Antifungal Agents
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Antineoplastic Agents
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Antiviral Agents
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Pyrazoles