Abstract
A new rat anti-mouse mAb, designated S7, is described. The antibody, an IgG2a, reacts with all Thy-1.2-positive cells and all granulocytic cells in the marrow. Resting B cells are non-reactive but, during the terminal phases of LPS-induced B cell differentiation, the S7 determinant appears and reaches high levels of expression. S7 will probably be useful in studies aimed at subdividing the later stages of the B cell maturation process.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Monoclonal / immunology
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Antigen-Antibody Reactions
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Antigens, Surface / immunology
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Antigens, Surface / isolation & purification*
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B-Lymphocytes / classification
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B-Lymphocytes / cytology*
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B-Lymphocytes / immunology
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Bone Marrow Cells
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Cell Differentiation*
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Granulocytes / immunology
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Immunoglobulin M
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Lymphocyte Activation*
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Male
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Mice
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Mice, Inbred BALB C
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Molecular Weight
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Phenotype
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Rats
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Receptors, Antigen, B-Cell
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Spleen / cytology
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T-Lymphocytes / analysis*
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T-Lymphocytes / classification
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T-Lymphocytes / immunology
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Thy-1 Antigens
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Tumor Necrosis Factor Receptor Superfamily, Member 7
Substances
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Antibodies, Monoclonal
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Antigens, Surface
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Immunoglobulin M
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Receptors, Antigen, B-Cell
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Thy-1 Antigens
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Tumor Necrosis Factor Receptor Superfamily, Member 7