A novel 111-nucleotide duplication in the G gene of human metapneumovirus

Miwako Saikusa; Naganori Nao; Chiharu Kawakami; Shuzo Usuku; Tadayoshi Sasao; Takahiro Toyozawa; Makoto Takeda; Ichiro Okubo

doi:10.1111/1348-0421.12543

A novel 111-nucleotide duplication in the G gene of human metapneumovirus

Microbiol Immunol. 2017 Nov;61(11):507-512. doi: 10.1111/1348-0421.12543.

Authors

Miwako Saikusa¹, Naganori Nao², Chiharu Kawakami¹, Shuzo Usuku¹, Tadayoshi Sasao¹, Takahiro Toyozawa³, Makoto Takeda², Ichiro Okubo¹

Affiliations

¹ Yokohama City Institute of Public Health, Yokohama 236-0051, Kanagawa, Japan.
² Department of Virology 3, National Institute of Infectious Diseases, Musashimurayama, 208-0011, Tokyo, Japan.
³ Yokohama City Public Health Center, Yokohama 231-0017, Kanagawa, Japan.

PMID: 28960538
DOI: 10.1111/1348-0421.12543

Abstract

In 2017, novel human metapneumovirus (HMPV) A2b subgroup strains with a 111-nucleotide duplication in the G gene was detected by the present team. These strains were related to previously identified HMPV A2b strains with a 180-nucleotide duplication; however, they appeared to be different strains, produced by an independent duplication event. The recent evolution of HMPV suggests that careful monitoring of this virus is required.

Keywords: G gene; duplication; human metapneumovirus.

MeSH terms

Amino Acid Sequence
Base Sequence
Child, Preschool
Female
Genetic Variation
Genotype
Humans
Infant
Male
Metapneumovirus / classification
Metapneumovirus / genetics*
Metapneumovirus / isolation & purification*
Molecular Sequence Data
Paramyxoviridae Infections / virology*
Phylogeny
RNA, Viral / genetics
Viral Envelope Proteins / genetics*
Viral Envelope Proteins / metabolism

Substances

RNA, Viral
Viral Envelope Proteins