1 aDepartment of Cardiology and Clinical Research, Inselspital Bern, University of Bern, Bern, Switzerland bMount Sinai Icahn School of Medicine, New York, New York, USA cJagiellonian University Krakow, Kraków, Poland dDepartment of Clinical and Experimental Sciences, Clinica Medica, University of Brescia, Brescia, Italy eService de Néphrologie et Hypertension, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland fDepartment of Biomedical Sciences, Pacific Northwest University of Health Sciences, Yakima, Washington gHeart Disease Prevention Program, Division of Cardiology, Department of Medicine, C240 Medical Sciences, University of California, Irvine, California, USA hDepartment of Internal Medicine and Gerontology, Jagiellonian University Medical College, Krakow, Poland iDivision of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine,Tochigi, Japan jDepartment of Cardiology, University of Oslo, Ullevaal Hospital, Oslo, Norway kCardiovascular Institute, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA lDepartment of Pharmacology, European Georges Pompidou Hospital, Assistance Publique Hôpitaux de Paris, Inserm UMR 970, University Paris Descartes, Paris, France mHypertension Unit, University of Ottawa Heart Institute, Ottawa, Ontario, Canada nDepartment of Medicine, Maastricht University Medical Center, Maastricht University, Maastricht, the Netherlands oDepartment of Heart Diseases, University of Bergen, Haukeland Hospital, Bergen, Norway pUniversity of Milano-Bicocca qIRCCS Istituto Auxologico Italiano, Milan, Italy rDepartment of Hypertension and Diabetology, Medical University of Gdańsk, Gdańsk, Poland sHypertension and Cardiovascular Research Clinic, Veterans Affairs and Georgetown University Medical Centers, Washington, District of Columbia, USA tDepartment of Cardiovascular, Neural and Metabolic Sciences, Ospedale S. Luca IRCCS Istituto Auxologico Italiano uDepartment of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy vImperial Clinical Trials Unit, Imperial College London, London, UK wHospital Clinico Unviersitario de Valencia, Valencia xDepartment of Nephrology, Hypertension Unit, Hospital 12 de Octubre, Madrid, Spain yDepartment of Medicine, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Québec, Canada zDepartment of Nephrology and Hypertension, Friedrich-Alexander- University Erlangen-Nürnberg (FAU), Erlangen, Germany aaDivision of Nephrology and Hypertension, Department of Medicine bbAmerican Society of Hypertension, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA ccInternational Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London - Hammersmith Campus, London, UK ddDiabetes and Cardiovascular Center, University of Missouri School of Medicine eeDepartment Service, Harry S Truman Memorial Veterans Hospital ffDepartment of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, Missouri, USA ggUniversity of Leuven, Leuven, Belgium hhDepartment of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China iiSUNY Downstate Medical Center, Brooklyn, New York, USA jjUniversity College London and NIHR University College London Hospitals Biomedical Research Centre, University College London, London, UK.