The etiology of Major Depressive Disorder (MDD) is still unclear. We reviewed the literature for the relationship between inflammatory signaling and cytokines in the pathogenesis of MDD. In addition, we provid evidence for adjunctive treatment using anti-inflammatory drugs to improve the therapeutic effect and prognosis. Finally, we explore the possible relationship between the pathogenesis of MDD and immune disturbances.
抑郁障碍病因仍不清楚。本文综述了相关文献， 提供了炎症信号和细胞因子在抑郁障碍的发病机制中 的作用、 及抗炎机制药物的辅助性治疗对提高抑郁症 治疗疗效、 改善预后的证据， 并进一步探讨了抑郁障 碍发病机制与免疫异常的可能联系。.
Keywords: China; cytokines; major depressive disorder; neuroimmunology.