Improved Bactec MGIT 960 Pyrazinamide Test Decreases Detection of False Mycobacterium tuberculosis Pyrazinamide Resistance

J Clin Microbiol. 2017 Dec;55(12):3552-3553. doi: 10.1128/JCM.01437-17. Epub 2017 Sep 13.

Authors

Alessandro Mustazzolu¹, Angelo Iacobino¹, Federico Giannoni¹, Claudio Piersimoni²; Italian Multicentre Study on Resistance to Antituberculosis Drugs (SMIRA) Group; Lanfranco Fattorini³

Affiliations

¹ Istituto Superiore di Sanità, Department of Infectious Diseases, Rome, Italy.
² Regional Reference Mycobacteria Laboratory, United Hospitals, Ancona, Italy.
³ Istituto Superiore di Sanità, Department of Infectious Diseases, Rome, Italy lanfranco.fattorini@iss.it.

No abstract available

Keywords: Bactec MGIT 960; Mycobacterium tuberculosis; false resistance; pyrazinamide; tuberculosis.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Amidohydrolases / genetics
Antitubercular Agents / pharmacology*
Diagnostic Errors / prevention & control*
Drug Resistance, Bacterial / drug effects*
Drug Resistance, Bacterial / genetics
Humans
Microbial Sensitivity Tests / methods*
Mutation
Mycobacterium tuberculosis / classification
Mycobacterium tuberculosis / drug effects*
Mycobacterium tuberculosis / genetics
Pyrazinamide / pharmacology*
Tuberculosis / diagnosis
Tuberculosis / microbiology

Substances

Antitubercular Agents
Pyrazinamide
Amidohydrolases
PncA protein, Mycobacterium tuberculosis