Dermatopathic lymphadenopathy with Langerhans cell chimerism in graft-versus-host disease of the skin

Eur J Haematol. 2017 Dec;99(6):582-585. doi: 10.1111/ejh.12968. Epub 2017 Oct 4.

Abstract

Dermatopathic lymphadenopathy (DL) is well-known in inflammatory skin disease; however, it has not been reported in graft-versus-host disease (GvHD) after allogeneic stem cell transplantation. Here, we report 2 cases of DL in patients with acute GvHD of the skin and demonstrate complete donor chimerism of Langerhans cells within the lymph nodes.

Keywords: Langerhans cell; dermatopathic lymphadenopathy; graft-versus-host disease.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biopsy
  • Female
  • Graft vs Host Disease / diagnosis*
  • Graft vs Host Disease / etiology*
  • Hematopoietic Stem Cell Transplantation / adverse effects
  • Hematopoietic Stem Cell Transplantation / methods
  • Humans
  • Langerhans Cells / pathology*
  • Lymphadenopathy / diagnosis*
  • Lymphadenopathy / etiology*
  • Lymphoma, T-Cell / complications
  • Lymphoma, T-Cell / diagnosis
  • Lymphoma, T-Cell / therapy
  • Male
  • Skin Diseases / diagnosis*
  • Skin Diseases / etiology*
  • Transplantation Chimera