Abstract
Macrocyclic peptide-based natural products have provided powerful new antibiotic drugs, drug candidates, and scaffolds for medicinal chemists as a source of inspiration to design novel antibiotics. While most of those natural products are active mainly against Gram-positive pathogens, novel macrocyclic peptide-based compounds have recently been described, which exhibit potent and specific activity against some of the most problematic Gram-negative ESKAPE pathogens. This mini-review gives an up-date on recent developments.
Keywords:
Antibiotics; Gram-negative ESKAPE pathogens; Macrocyclic peptides and depsipetides; Outer-membrane protein targeting antibiotics (OMPTA).
Copyright © 2017 Elsevier Ltd. All rights reserved.
MeSH terms
-
Animals
-
Anti-Bacterial Agents / chemistry*
-
Anti-Bacterial Agents / pharmacology*
-
Anti-Bacterial Agents / therapeutic use
-
Bacteria / drug effects
-
Bacterial Infections / drug therapy
-
Bacterial Outer Membrane Proteins / metabolism
-
Clinical Trials as Topic
-
Depsipeptides / chemistry
-
Depsipeptides / pharmacology
-
Depsipeptides / therapeutic use
-
Drug Discovery / methods*
-
Humans
-
Macrocyclic Compounds / chemistry*
-
Macrocyclic Compounds / pharmacology*
-
Macrocyclic Compounds / therapeutic use
-
Models, Molecular
-
Peptides, Cyclic / chemistry*
-
Peptides, Cyclic / pharmacology*
-
Peptides, Cyclic / therapeutic use
Substances
-
Anti-Bacterial Agents
-
Bacterial Outer Membrane Proteins
-
Depsipeptides
-
Macrocyclic Compounds
-
Peptides, Cyclic