Japanese genome-wide association study identifies a significant colorectal cancer susceptibility locus at chromosome 10p14

Yusuke Takahashi; Keishi Sugimachi; Ken Yamamoto; Atsushi Niida; Teppei Shimamura; Tetsuya Sato; Masahiko Watanabe; Junichi Tanaka; Shinei Kudo; Kenichi Sugihara; Kazuo Hase; Masato Kusunoki; Kazutaka Yamada; Yasuhiro Shimada; Yoshihiro Moriya; Yutaka Suzuki; Satoru Miyano; Masaki Mori; Koshi Mimori

doi:10.1111/cas.13391

Japanese genome-wide association study identifies a significant colorectal cancer susceptibility locus at chromosome 10p14

Cancer Sci. 2017 Nov;108(11):2239-2247. doi: 10.1111/cas.13391. Epub 2017 Sep 26.

Authors

Yusuke Takahashi^{1

2}, Keishi Sugimachi^{1

3}, Ken Yamamoto⁴, Atsushi Niida⁵, Teppei Shimamura^{5

6}, Tetsuya Sato⁷, Masahiko Watanabe⁸, Junichi Tanaka⁹, Shinei Kudo⁹, Kenichi Sugihara¹⁰, Kazuo Hase¹¹, Masato Kusunoki¹², Kazutaka Yamada¹³, Yasuhiro Shimada¹⁴, Yoshihiro Moriya¹⁴, Yutaka Suzuki¹⁵, Satoru Miyano⁵, Masaki Mori², Koshi Mimori¹

Affiliations

¹ Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan.
² Department of Gastroenterological Surgery, Osaka University, Suita, Japan.
³ Department of Hepatobiliary-pancreatic surgery, National Kyushu Cancer Center, Fukuoka, Japan.
⁴ Department of Medical Biochemistry, Kurume University, Kurume, Japan.
⁵ Laboratory of DNA Information Analysis, Human Genome Center Institute of Medical Science, University of Tokyo, Tokyo, Japan.
⁶ Division of System Biology, Graduate School of Medicine, Nagoya University, Nagoya, Japan.
⁷ Division of Bioinformatics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
⁸ Department of Surgery, Kitazato University, Sagamihara, Japan.
⁹ Digestive Disease Center, Northern Yokohama Hospital, Showa University, Yokohama, Japan.
¹⁰ Department of Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
¹¹ Department of Surgery, National Defense University, Tokorozawa, Japan.
¹² Department of Surgery, Mie University, Tsu, Japan.
¹³ Department of Surgery, Takano Hospital, Kumamoto, Japan.
¹⁴ Department of Surgery and Digestive Tract Medicine, National Cancer Center, Tokyo, Japan.
¹⁵ Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Japan.

Abstract

Genome-wide association studies are a powerful tool for searching for disease susceptibility loci. Several studies identifying single nucleotide polymorphisms (SNP) connected intimately to the onset of colorectal cancer (CRC) have been published, but there are few reports of genome-wide association studies in Japan. To identify genetic variants that modify the risk of CRC oncogenesis, especially in the Japanese population, we performed a multi-stage genome-wide association study using a large number of samples: 1846 CRC cases and 2675 controls. We identified 4 SNP (rs7912831, rs4749812, rs7898455 and rs10905453) in chromosome region 10p14 associated with CRC; however, there are no coding or non-coding genes within this region of fairly extensive linkage disequilibrium (a 500-kb block) on 10p14. Our study revealed that the 10p14 locus is significantly correlated with susceptibility to CRC in the Japanese population, in accordance with the results of multiple studies in other races.

Keywords: 10p14; Colorectal cancer; Japanese; genome-wide association study; single nucleotide polymorphism.

MeSH terms

Chromosomes, Human, Pair 10 / genetics
Colorectal Neoplasms / genetics*
Colorectal Neoplasms / pathology
Female
Genetic Predisposition to Disease*
Genome-Wide Association Study*
Genotype
Humans
Japan
Linkage Disequilibrium
Male
Middle Aged
Polymorphism, Single Nucleotide / genetics*