Yttrium-Catalyzed Tandem Intermolecular Hydroalkoxylation/Claisen Rearrangement

J Org Chem. 2017 Oct 6;82(19):10149-10157. doi: 10.1021/acs.joc.7b01612. Epub 2017 Sep 11.

Abstract

An efficient yttrium-catalyzed tandem intermolecular hydroalkoxylation/Claisen rearrangement has been developed, providing various γ,δ-unsaturated amides in generally good to excellent yields. Importantly, high Z/E selectivity and diastereoselectivity were achieved. Other notable features of this method include widespread availability of the substrates, compatibility with a broad range of functional groups, and mild reaction conditions.

Publication types

  • Research Support, Non-U.S. Gov't