Biotin-tagged platinum(iv) complexes as targeted cytostatic agents against breast cancer cells

Chem Commun (Camb). 2017 Sep 5;53(72):9971-9974. doi: 10.1039/c7cc05311h.

Abstract

A biotin-guided platinumIV complex is highly cytotoxic against breast cancer cells but hypotoxic against mammary epithelial cells. The mono-biotinylated PtIV complex is superior to the di-biotinylated one and hence a promising drug candidate for the targeted therapy of breast cancer.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacokinetics
  • Antineoplastic Agents / pharmacology*
  • Biotin / analogs & derivatives*
  • Biotin / chemical synthesis
  • Biotin / pharmacokinetics
  • Biotin / pharmacology*
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / pathology
  • Cattle
  • Cell Line, Tumor
  • Cisplatin / pharmacology
  • Coordination Complexes / chemical synthesis
  • Coordination Complexes / chemistry
  • Coordination Complexes / pharmacokinetics
  • Coordination Complexes / pharmacology*
  • DNA / chemistry
  • Epithelial Cells / drug effects
  • Epithelial Cells / pathology
  • Female
  • Humans
  • Oxidation-Reduction
  • Platinum*

Substances

  • Antineoplastic Agents
  • Coordination Complexes
  • Platinum
  • Biotin
  • DNA
  • calf thymus DNA
  • Cisplatin