1 Department of Medicine, McMaster University, Hamilton, ON, Canada and Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada, Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada, and St Joseph's Healthcare Hamilton, Hamilton, ON, Canada; St Joseph's Healthcare Hamilton, Hamilton, ON, Canada; Derriford Hospital, Plymouth Hospitals NHS Trust, Plymouth, Devon, United Kingdom and Faculty of Health and Human Sciences, University of Plymouth, Devon, United Kingdom; Department of Medicine, McMaster University, Hamilton, ON, Canada, Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada, and St Joseph's Healthcare Hamilton, Hamilton, ON, Canada.