Complete genome sequence of a novel, virulent Ahjdlikevirus bacteriophage that infects Enterococcus faecium

Arch Virol. 2017 Dec;162(12):3843-3847. doi: 10.1007/s00705-017-3503-1. Epub 2017 Aug 16.

Abstract

A novel virulent bacteriophage named vB_EfaP_IME199 that specifically infects Enterococcus faecium was isolated and characterized. Its optimal multiplicity of infection was 0.01, and it had a 30 minute outbreak period. High-throughput sequencing revealed that the phage has a dsDNA genome of 18,838 bp with 22 open reading frames. The genome has very low homology to all other bacteriophage sequences in the GenBank database. Run-off sequencing experiments confirmed that vB_EfaP_IME199 has short inverted terminal repeats. Phylogenetic analysis indicated that vB_EfaP_IME199 can be taxonomically classified as a new member of the genus Ahjdlikevirus of family Podoviridae.

MeSH terms

  • Bacteriophages / classification*
  • Bacteriophages / genetics
  • Bacteriophages / isolation & purification*
  • DNA / chemistry
  • DNA / genetics
  • Enterococcus faecium / virology*
  • Genome, Viral*
  • High-Throughput Nucleotide Sequencing
  • Open Reading Frames
  • Phylogeny
  • Podoviridae / classification*
  • Podoviridae / genetics
  • Podoviridae / growth & development
  • Podoviridae / isolation & purification*
  • Sequence Analysis, DNA*
  • Sequence Homology

Substances

  • DNA