Esophagectomy for patients with esophageal cancer is one of the most invasive surgery. Despite advances in surgical techniques and perioperative management, both morbidity and mortality rates after esophagectomy still remains high. Recently, it was suggested that perioperative care bundle is effective for preventing postoperative complications after esophagectomy. Then, we introduced a perioperative multidisciplinary management team, which aimed at systematic perioperative care for patients undergoing esophagectomy. This care bundle mainly included cessation of smoking and drinking, dental cleaning, medication assistance, physical exercise and rehabilitation, respiratory training, and nutritional support. These systematic and cooperative interventions by professionals can decrease the incidence of postoperative complications after esophagectomy.