Prostate cancer: The influence of steroid metabolism on CYP17A1 inhibitor activity

Nat Rev Urol. 2017 Oct;14(10):590-592. doi: 10.1038/nrurol.2017.132. Epub 2017 Aug 8.

Authors

Frank Claessens¹, Lisa Moris²

Affiliations

¹ Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, Campus Gasthuisberg, Herestraat 49, PO Box 901, 3000 Leuven, Belgium.
² Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, Campus Gasthuisberg, Herestraat 49, PO Box 901, 3000 Leuven, Belgium; and at the Department of Urology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium.

PMID: 28786422
DOI: 10.1038/nrurol.2017.132

No abstract available

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MeSH terms

Androstadienes*
Benzimidazoles
Humans
Male
Prostatic Neoplasms*
Steroid 17-alpha-Hydroxylase

Substances

Androstadienes
Benzimidazoles
CYP17A1 protein, human
Steroid 17-alpha-Hydroxylase
3-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene