Virtual protein purification: A simple exercise to introduce ph as a parameter that effects ion exchange chromatography

Biochem Mol Biol Educ. 2018 Jan;46(1):91-97. doi: 10.1002/bmb.21082. Epub 2017 Aug 6.

Abstract

This article describes a simple exercise using a free, easy-to-use, established online program. The exercise helps to reinforce protein purification concepts and introduces undergraduates to pH as a parameter that affects anion-exchange chromatography. The exercise was tested with biochemistry majors at California State University-Chico. Given the versatility of the program, this work is also a model for instructors that wish to develop their own exercise to help teach other protein purification techniques. © 2017 by The International Union of Biochemistry and Molecular Biology, 46(1):91-97, 2018.

Keywords: Protein purification; computer software; ion exchange; web-assisted learning.

MeSH terms

  • Biochemistry / education*
  • Chromatography, Ion Exchange / methods*
  • Hydrogen-Ion Concentration
  • Internet
  • Proteins / chemistry
  • Proteins / isolation & purification*
  • Students
  • Teaching*
  • Universities

Substances

  • Proteins