Differential changes of nuclear-envelope-associated enzyme activities involved in nucleocytoplasmic mRNA transport in the developing rat brain and liver

Biochim Biophys Acta. 1986 Nov 13;868(2-3):108-18. doi: 10.1016/0167-4781(86)90013-8.

Abstract

Nucleocytoplasmic transport of rat liver mRNA is thought to be regulated by a nucleoside triphosphatase whose activity in the intact nuclear envelope is stimulated by the 3'poly(A) tail of poly(A)+ mRNA. In contrast to the liver mRNA, the mRNA from rat brain contains a great population of poly(A)- mRNA's that does not appear until after birth. Measurements of the nuclear-envelope-associated enzyme activities involved in mRNA transport, and their dependence on endogenous (isolated cytoplasmic mRNA-transport-stimulating proteins) and exogenous (poly(A), lectins, and neoglycoproteins) factors during prenatal and postnatal rat brain and liver development, revealed marked organ-dependent differences paralleling the appearance of the poly(A)- mRNA unique in the brain.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biological Transport
  • Brain / growth & development
  • Brain / metabolism*
  • Carrier Proteins / metabolism
  • Cell Nucleus / metabolism
  • Cytoplasm / metabolism
  • Enzyme Activation / drug effects
  • Glycoproteins / pharmacology
  • Lectins / pharmacology
  • Liver / growth & development
  • Liver / metabolism*
  • Nuclear Envelope / enzymology
  • Nucleocytoplasmic Transport Proteins*
  • Nucleoside-Triphosphatase
  • Phosphoric Monoester Hydrolases / metabolism
  • Poly A / metabolism*
  • Poly A / pharmacology
  • RNA, Messenger / metabolism*
  • RNA-Binding Proteins*
  • Rats
  • Rats, Inbred Strains

Substances

  • Carrier Proteins
  • Glycoproteins
  • Lectins
  • Nucleocytoplasmic Transport Proteins
  • RNA, Messenger
  • RNA-Binding Proteins
  • Poly A
  • Phosphoric Monoester Hydrolases
  • Nucleoside-Triphosphatase