PEGylated (NH4)xWO3 nanorods as efficient and stable multifunctional nanoagents for simultaneous CT imaging and photothermal therapy of tumor

Daniel K Macharia; Qiyun Tian; Liang Chen; Yingqi Sun; Nuo Yu; Chuanglong He; Han Wang; Zhigang Chen

doi:10.1016/j.jphotobiol.2017.07.006

PEGylated (NH₄)_xWO₃ nanorods as efficient and stable multifunctional nanoagents for simultaneous CT imaging and photothermal therapy of tumor

J Photochem Photobiol B. 2017 Sep:174:10-17. doi: 10.1016/j.jphotobiol.2017.07.006. Epub 2017 Jul 18.

Authors

Daniel K Macharia¹, Qiyun Tian², Liang Chen³, Yingqi Sun², Nuo Yu¹, Chuanglong He³, Han Wang⁴, Zhigang Chen⁵

Affiliations

¹ State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China.
² Department of Radiology and Experimental Research Center, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200080, China.
³ College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, China.
⁴ Department of Radiology and Experimental Research Center, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200080, China. Electronic address: drwangh@sina.com.
⁵ State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China. Electronic address: zgchen@dhu.edu.cn.

PMID: 28750318
DOI: 10.1016/j.jphotobiol.2017.07.006

Abstract

The simultaneous imaging and photothermal therapy of tumors have attracted much attention, and a prerequisite is to obtain multifunctional nanomaterials. Ideally, one kind of nanoparticles with single component can be used as both imaging agent and photothermal agent. Herein, we have developed the PEGylated (NH₄)_xWO₃ (denoted as (NH₄)_xWO₃-PEG) nanorods as multifunctional nanoparticles with single semiconductor component. (NH₄)_xWO₃-PEG nanorods with about 30nm diameter and length of several hundred nanometers have been obtained through a solvothermal synthesis-PEGylation two-step route. Under the irradiation of 980-nm laser with intensity of 0.72Wcm^-2, aqueous dispersion of (NH₄)_xWO₃-PEG nanorods (0.67-5.44mmol/L) displays high elevation (17.6-34.5°C) of temperature in 400s, accompanied by an excellent long-term photothermal stability. Furthermore, (NH₄)_xWO₃-PEG nanorods exhibit as high as 6 times X-ray attenuation ability compared to that of the clinically used iodine-based X-ray computed tomography (CT) contrast agent (Iopromide). More importantly, after PBS solution of (NH₄)_xWO₃-PEG nanorods is injected into the tumor of mice, the tumor can be effectively detected by CT imaging. Moreover, cancer cells in vivo can be further destroyed by the photothermal effects of (NH₄)_xWO₃-PEG nanorods, under the irradiation of 980-nm laser with the safe intensity of 0.72Wcm^-2 for 10min. Therefore, (NH₄)_xWO₃-PEG nanorods can be used as a new kind of stable and efficient multifunctional nanoagent with single component for simultaneous CT imaging and photothermal therapy of tumor.

Keywords: (NH(4))(x)WO(3); CT imaging; Multifunctional nanoagents; Near-infrared laser; Photothermal therapy; Tumor.

MeSH terms

Adenocarcinoma / diagnostic imaging*
Adenocarcinoma / pathology
Adenocarcinoma / therapy*
Adenocarcinoma of Lung
Animals
Cell Transformation, Neoplastic
Drug Stability
HeLa Cells
Humans
Lung Neoplasms / diagnostic imaging*
Lung Neoplasms / pathology
Lung Neoplasms / therapy*
Mice
Mice, Nude
Nanotubes*
Oxides / chemistry
Oxides / therapeutic use*
Phototherapy / methods*
Polyethylene Glycols / chemistry*
Theranostic Nanomedicine
Tomography, X-Ray Computed / methods*
Tungsten / chemistry
Tungsten / therapeutic use*

Substances

Oxides
Polyethylene Glycols
tungsten oxide
Tungsten