Tumor-Stromal Cell Communication: Small Vesicles Signal Big Changes

Franz Wendler; Gordon W Stamp; Georgios Giamas

doi:10.1016/j.trecan.2016.05.007

Tumor-Stromal Cell Communication: Small Vesicles Signal Big Changes

Trends Cancer. 2016 Jul;2(7):326-329. doi: 10.1016/j.trecan.2016.05.007. Epub 2016 Jun 11.

Authors

Franz Wendler¹, Gordon W Stamp², Georgios Giamas³

Affiliations

¹ University of Sussex, School of Life Sciences, John Maynard Smith Building, Falmer, Brighton BN1 9QG, UK. Electronic address: f.wendler@sussex.ac.uk.
² Division of Diabetes, Endocrinology, and Metabolism, Imperial College Hammersmith Campus, Du Cane Road, London W12 0NN, UK.
³ University of Sussex, School of Life Sciences, John Maynard Smith Building, Falmer, Brighton BN1 9QG, UK. Electronic address: g.giamas@sussex.ac.uk.

PMID: 28741534
DOI: 10.1016/j.trecan.2016.05.007

Abstract

Reciprocal interactions between malignant and stromal cells create a local microenvironment that fosters tumor growth. Extracellular vesicles (EVs) such as exosomes, microvesicles, and large oncosomes are involved in tumor-stroma communication by shuttling signaling cargo and other molecules. Here we discuss how EVs released by cancer or stromal cells impact the proliferation, differentiation, and metabolism of tumors.

Keywords: TGFβ; cancer-associated fibroblasts; exosomes; extracellular vesicles; microenvironment; stroma.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Extracellular Vesicles / pathology*
Fibroblasts
Lymphatic Vessels
Neoplasms / immunology
Neoplasms / pathology*
Signal Transduction
Stromal Cells / pathology*
Tumor Microenvironment*