Commensal bacteria (ab)use CD8⁺ T cells to induce insulin resistance

Sci Immunol. 2017 Apr 21;2(10):eaan1473. doi: 10.1126/sciimmunol.aan1473.

Authors

Chi Ma¹, Tim F Greten²

Affiliations

¹ GI-Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
² GI-Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. tim.greten@nih.gov.

PMID: 28738021
DOI: 10.1126/sciimmunol.aan1473

Abstract

Type I interferon-dependent expansion of intrahepatic CD8⁺ T cells promotes systemic insulin resistance in obesity.

Copyright © 2017, American Association for the Advancement of Science.

Publication types

Review