Emotional fMR auditory paradigm demonstrates normalization of limbic hyperactivity after cognitive behavior therapy for auditory hallucinations

Eduardo J Aguilar; Iluminada Corripio; Gracián García-Martí; Eva Grasa; Luis Martí-Bonmatí; Beatriz Gómez-Ansón; Julio Sanjuán; Fidel Núñez-Marín; Esther Lorente-Rovira; María J Escartí; Alison Brabban; Douglas Turkington

doi:10.1016/j.schres.2017.07.024

Emotional fMR auditory paradigm demonstrates normalization of limbic hyperactivity after cognitive behavior therapy for auditory hallucinations

Schizophr Res. 2018 Mar:193:304-312. doi: 10.1016/j.schres.2017.07.024. Epub 2017 Jul 15.

Affiliations

¹ Department of Medicine, Valencia University, Avda. Blasco Ibáñez 15-17, 46010 Valencia, Spain; INCLIVA Health Research Institute, Clinical University Hospital, Avda. Blasco Ibáñez 17, 46010 Valencia, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), C/ Monforte de Lemos 3-5, Pabellón 6-Sótano, 28029 Madrid, Spain. Electronic address: eduardoj.aguilar@gmail.com.
² Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), C/ Monforte de Lemos 3-5, Pabellón 6-Sótano, 28029 Madrid, Spain; Psychiatry Unit, Institut d'Investigació Biomèdica-Sant Pau (IIB-Sant Pau), Santa Creu i Sant Pau Hospital, C/ Sant Quintí, 89, 08026 Barcelona, Spain; Autonoma University, Plaça Cívica, Campus de la UAB, 08193 Cerdanyola del Vallés Barcelona, Spain. Electronic address: icorripio@santpau.cat.
³ Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), C/ Monforte de Lemos 3-5, Pabellón 6-Sótano, 28029 Madrid, Spain; Radiology Department, Quirón Hospital, Avda. Blasco Ibáñez 14, 46010 Valencia, Spain. Electronic address: gracian.garcia@quironsalud.es.
⁴ Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), C/ Monforte de Lemos 3-5, Pabellón 6-Sótano, 28029 Madrid, Spain; Psychiatry Unit, Institut d'Investigació Biomèdica-Sant Pau (IIB-Sant Pau), Santa Creu i Sant Pau Hospital, C/ Sant Quintí, 89, 08026 Barcelona, Spain; Autonoma University, Plaça Cívica, Campus de la UAB, 08193 Cerdanyola del Vallés Barcelona, Spain. Electronic address: egrasa@santpau.cat.
⁵ Department of Medicine, Valencia University, Avda. Blasco Ibáñez 15-17, 46010 Valencia, Spain; Radiology Department, Quirón Hospital, Avda. Blasco Ibáñez 14, 46010 Valencia, Spain; Radiology Department and GIBI230 Research Group, La Fe University and Polytechnic Hospital, Bulevar Sur, s/n, 46026 Valencia, Spain. Electronic address: luis.Marti@uv.es.
⁶ Autonoma University, Plaça Cívica, Campus de la UAB, 08193 Cerdanyola del Vallés Barcelona, Spain; Neuroradiology Unit, Radiology Department, Neuroradiology Research Group, Institut d'Investigació Biomèdica-Sant Pau (IIB-Sant Pau), Santa Creu i Sant Pau Hospital, C/ Sant Quintí, 89, 08026 Barcelona, Spain. Electronic address: BGomezA@santpau.cat.
⁷ Department of Medicine, Valencia University, Avda. Blasco Ibáñez 15-17, 46010 Valencia, Spain; INCLIVA Health Research Institute, Clinical University Hospital, Avda. Blasco Ibáñez 17, 46010 Valencia, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), C/ Monforte de Lemos 3-5, Pabellón 6-Sótano, 28029 Madrid, Spain. Electronic address: Julio.Sanjuan@uv.es.
⁸ Autonoma University, Plaça Cívica, Campus de la UAB, 08193 Cerdanyola del Vallés Barcelona, Spain; Neuroradiology Unit, Radiology Department, Neuroradiology Research Group, Institut d'Investigació Biomèdica-Sant Pau (IIB-Sant Pau), Santa Creu i Sant Pau Hospital, C/ Sant Quintí, 89, 08026 Barcelona, Spain. Electronic address: FNunez@santpau.cat.
⁹ INCLIVA Health Research Institute, Clinical University Hospital, Avda. Blasco Ibáñez 17, 46010 Valencia, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), C/ Monforte de Lemos 3-5, Pabellón 6-Sótano, 28029 Madrid, Spain. Electronic address: esterlorente@hotmail.com.
¹⁰ INCLIVA Health Research Institute, Clinical University Hospital, Avda. Blasco Ibáñez 17, 46010 Valencia, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), C/ Monforte de Lemos 3-5, Pabellón 6-Sótano, 28029 Madrid, Spain. Electronic address: mescarti92@gmail.com.
¹¹ Durham University, Stockton Rd, Durham, County Durham DH1, United Kingdom. Electronic address: abrabban@btopenworld.com.
¹² Newcastle University, Newcastle upon Tyne, Tyne and Wear NE1 7RU, United Kingdom. Electronic address: Douglas.Turkington@ntw.nhs.uk.

PMID: 28720416
DOI: 10.1016/j.schres.2017.07.024

No abstract available

Keywords: Cognitive behavior therapy; Emotional response; Functional magnetic resonance; Neuroimaging; Psychosis; Schizophrenia.

MeSH terms

Acoustic Stimulation
Adult
Analysis of Variance
Cognitive Behavioral Therapy / methods*
Emotions / physiology*
Female
Hallucinations / diagnostic imaging
Hallucinations / rehabilitation*
Humans
Image Processing, Computer-Assisted
Limbic System / diagnostic imaging*
Magnetic Resonance Imaging*
Male
Oxygen / blood
Time Factors

Substances

Oxygen