New connections: Amyloid-β, calcium, and the synapse

Sci Signal. 2017 Jul 11;10(487):eaao3024. doi: 10.1126/scisignal.aao3024.

Abstract

Insight into how amyloid-β impairs synaptic function reveals potential therapeutic targets for patients with Alzheimer's disease.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / metabolism*
  • Alzheimer Disease / pathology
  • Alzheimer Disease / therapy*
  • Amyloid beta-Peptides / metabolism*
  • Animals
  • Calcium / metabolism*
  • Humans
  • Synapses / metabolism*
  • Synapses / pathology

Substances

  • Amyloid beta-Peptides
  • Calcium