Objective: To explore the effect of occupational exposure to glyphosate on hepatorenal function. Methods: 526 workers who were occupationally exposed to glyphosate from 5 glyphosate-producing factories were selected as cases; and another 442 administrative staffs who were not exposed to glyphosate were selected as controls from April to November, 2014. All the subjects accepted occupational health examination. The concentration level of glyphosate in the air of workshop was detected and the time weighted average concentration (TWA) was calculated. And analyze the difference of hepatorenal fuction between case group and control group. Result: The age of the subjects in the case and control groups were separately (35.6±10.3), (34.3±9.7) years old, with the length of working for (6.5±5.7), (7.7±6.8) years. The TWA of glyphosate in the case group was between <0.03-48.91 mg/m(3), with the geometric mean at 3.78 mg/m(3). The overall rates of abnormal hepatic and renal function in the case group were 14.4% (76 cases) and 16.2% (85 cases), respectively; while those were 5.0% (22 cases) and 4.8% (21 cases), respectively in control group, and the difference showed statistical significance (P<0.05). When TWA reached <0.03-6.00 mg/m(3), the difference of hepatorenal fuction between case group and control group showed statistical significance, and the rates of abnormal hepatic and renal function was 8.0% (36/447) and 9.8% (44/447) respectively in case group. When cumulative exposure level reached <1.56-68.64 g, the difference of hepatorenal fuction between case group and control group showed statistical significance, and the rates increased to 9.2% (37/404) and 10.4% (42/404) respectively in group of cases. Conclusion: Glyphosate can affect the hepatic and renal function among occupational exposure population, and there was an association between the effect and the exposure dose.
目的: 探讨职业性接触草甘膦对肝肾功能的影响。 方法: 于2014年4—11月,选取江苏、山东5家草甘膦生产企业的接触草甘膦工人作为接触组,共526名;以管理、后勤等非接触草甘膦工作人群作为对照组,共442名。进行职业健康检查,监测工作场所空气中草甘膦浓度,计算时间加权平均浓度(TWA)。比较接触组和对照组肝肾功能的差异。 结果: 接触组和对照组的年龄分别为(35.6±10.3)、(34.3±9.7)岁,工龄分别为(6.5±5.7)、(7.7±6.8)年。接触组接触空气中草甘膦TWA值在<0.03~48.91 mg/m(3)之间,几何均数为3.78 mg/m(3)。接触组肝肾功能损伤率分别为14.4%(76例)、16.2%(85例),对照组分别为5.0%(22例)、4.8%(21例),差异均有统计学意义(P值均<0.05)。当接触组接触草甘膦TWA值达到<0.03~6.00 mg/m(3)时,对照组与接触组对象肝肾功能异常差异出现统计学意义,肝、肾功能异常率分别为8.0%(36/447)、9.8%(44/447);当接触组草甘膦累积暴露剂量达到<1.56~68.64 g时,对照组与接触组对象肝肾功能异常差异出现统计学意义,肝、肾功能异常率分别为9.2%(37/404)、10.4%(42/404)。 结论: 职业接触草甘膦对人群肝肾功能有一定的影响,且损伤与接触剂量存在关联。.
Keywords: Glyphosate; Kidney; Liver; Occupational exposure.