Abstract
This study introduces a novel class of imidazolium- and ammonium-based ionic liquids possessing two C12 and C14 tails and thioether linkers designed for lipoplex-mediated DNA delivery. Imidazolium-based ionic liquids displayed efficient gene delivery properties with low toxicity. Thiol-yne click chemistry was employed for the facile and robust synthesis of these thioether-based cationic lipioids with enhanced lipophilicity and low fluidity.
MeSH terms
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Ammonium Compounds / chemistry
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Ammonium Compounds / pharmacology
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Cations / chemical synthesis
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Cations / chemistry
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Cations / pharmacology
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Cell Survival / drug effects
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Click Chemistry
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DNA / genetics*
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Dose-Response Relationship, Drug
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Gene Transfer Techniques*
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HEK293 Cells
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HeLa Cells
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Humans
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Hydrophobic and Hydrophilic Interactions
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Imidazoles / chemistry
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Imidazoles / pharmacology
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Ionic Liquids / chemistry*
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Ionic Liquids / pharmacology
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Lipids / chemistry*
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Lipids / pharmacology
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Molecular Structure
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Plasmids
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Quantum Theory
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Structure-Activity Relationship
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Sulfides / chemistry*
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Sulfides / pharmacology
Substances
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Ammonium Compounds
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Cations
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Imidazoles
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Ionic Liquids
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Lipids
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Sulfides
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DNA