Expanding the Tissue Toolbox: Deriving Colon Tissue from Human Pluripotent Stem Cells

Lotte Bruens; Hugo J G Snippert

doi:10.1016/j.stem.2017.06.001

Expanding the Tissue Toolbox: Deriving Colon Tissue from Human Pluripotent Stem Cells

Cell Stem Cell. 2017 Jul 6;21(1):3-5. doi: 10.1016/j.stem.2017.06.001.

Authors

Lotte Bruens¹, Hugo J G Snippert²

Affiliations

¹ Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands.
² Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands. Electronic address: h.j.g.snippert@umcutrecht.nl.

PMID: 28686867
DOI: 10.1016/j.stem.2017.06.001

Abstract

Organoid technology holds great potential for disease modeling and regenerative medicine. In this issue of Cell Stem Cell, Múnera et al. (2017) establish the generation of pluripotent stem cell-derived colon organoids that upon transplantation in mice, resembling human colon to a large extent, opening up avenues to study disease pathogenesis in human colon tissue.

Publication types

Review

MeSH terms

Animals
Colon / cytology
Colon / metabolism*
Heterografts
Humans
Mice
Organoids / cytology
Organoids / metabolism*
Organoids / transplantation*
Pluripotent Stem Cells / cytology
Pluripotent Stem Cells / metabolism*