Successful long-term terbinafine therapy in an asthmatic patient with Aspergillus sensitization and bronchiectasis

Isabel Rodriguez-Goncer; Rob Niven; David W Denning

doi:10.1016/j.mmcr.2017.04.005

Successful long-term terbinafine therapy in an asthmatic patient with Aspergillus sensitization and bronchiectasis

Med Mycol Case Rep. 2017 Apr 25:16:31-33. doi: 10.1016/j.mmcr.2017.04.005. eCollection 2017 Jun.

Authors

Isabel Rodriguez-Goncer¹, Rob Niven^{2

3}, David W Denning^{1

3}

Affiliations

¹ National Aspergillosis Centre, University Hospital of South Manchester, M23 9LT Manchester, UK.
² Severe Asthma Service, Department of Respiratory Medicine, University Hospital of South Manchester, M23 9LT Manchester, UK.
³ The University of Manchester and Manchester Academic Health Science Centre, Manchester, UK.

Abstract

Severe asthma with fungal sensitization (SAFS) is estimated to affect ~25% of patients with poorly controlled asthma. Tri-azole therapy is effective in only 60-80% and side effects are common. We report a 25 years-old woman with severe asthma, Aspergillus sensitization and marked bronchiectasis that developed a rare Achilles-tendinopathy with both itraconazole and voriconazole. She started a trial with terbinafine as salvage therapy that led to a striking improvement and long-term control of her respiratory disease.

Keywords: Aspergillus spp; Asthma; Bronchiectasis; Tendinopathy; Terbinafine.