Pericarditis during infliximab therapy in paediatric ulcerative colitis

J Clin Pharm Ther. 2018 Feb;43(1):107-109. doi: 10.1111/jcpt.12586. Epub 2017 Jun 23.

Abstract

What is known and study objective: Infliximab is a widely used drug for treating inflammatory bowel disease (IBD). This drug is known to rarely cause pericarditis in adult populations.

Case summary: This report details the case of a 14-year-old boy with ulcerative colitis who developed pericarditis after a second infliximab infusion. After discontinuation of therapy, the patient's symptoms were resolved.

What is new and conclusion: To our knowledge, this is the first reported paediatric case of pericarditis as a possible complication of infliximab therapy in IBD. Among infliximab-related delayed adverse reactions, cardiac complications should be monitored in the paediatric population.

Keywords: adverse event; drug-related; inflammatory bowel disease; infliximab; paediatric; pericarditis.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Colitis, Ulcerative / drug therapy*
  • Humans
  • Inflammatory Bowel Diseases / drug therapy
  • Infliximab / adverse effects*
  • Infliximab / therapeutic use*
  • Male
  • Pericarditis / chemically induced*

Substances

  • Infliximab

Supplementary concepts

  • Pediatric ulcerative colitis