Effect of N-acetylcysteine on pain in daily life in patients with sickle cell disease: a randomised clinical trial

Joep W R Sins; Karin Fijnvandraat; Anita W Rijneveld; Martine B Boom; Jean-Louis H Kerkhoffs; Alfred H van Meurs; Marco R de Groot; Harriët Heijboer; Marie-Françoise Dresse; Phu Quoc Lê; Philippe Hermans; Anna Vanderfaeillie; Eric W Van Den Neste; Fleur S Benghiat; Rachel Kesse-Adu; André Delannoy; André Efira; Marie-Agnès Azerad; Corianne A de Borgie; Bart J Biemond

doi:10.1111/bjh.14809

Effect of N-acetylcysteine on pain in daily life in patients with sickle cell disease: a randomised clinical trial

Br J Haematol. 2018 Aug;182(3):444-448. doi: 10.1111/bjh.14809. Epub 2017 Jun 23.

Authors

Joep W R Sins^{1

2}, Karin Fijnvandraat¹, Anita W Rijneveld³, Martine B Boom^{1

2}, Jean-Louis H Kerkhoffs⁴, Alfred H van Meurs⁵, Marco R de Groot⁶, Harriët Heijboer¹, Marie-Françoise Dresse⁷, Phu Quoc Lê⁸, Philippe Hermans⁹, Anna Vanderfaeillie¹⁰, Eric W Van Den Neste¹¹, Fleur S Benghiat¹², Rachel Kesse-Adu¹³, André Delannoy¹⁴, André Efira¹⁵, Marie-Agnès Azerad^{15

16}, Corianne A de Borgie¹⁷, Bart J Biemond²

Affiliations

¹ Department of Paediatric Haematology, Emma Children's Hospital, Academic Medical Centre, Amsterdam, the Netherlands.
² Department of Haematology, Academic Medical Centre, Amsterdam, the Netherlands.
³ Department of Haematology, Erasmus MC, Erasmus University Medical Centre, Rotterdam, the Netherlands.
⁴ Department of Haematology, Haga Hospital, the Hague, the Netherlands.
⁵ Department of Paediatrics, Haga Hospital, the Hague, the Netherlands.
⁶ Department of Haematology, University Medical Centre Groningen, Groningen, the Netherlands.
⁷ Department of Paediatric Haemato-oncology, Centre Hospitalier Régional de la Citadelle, Liège, Belgium.
⁸ Department of Haemato-oncology, Hôpital Universitaire des Enfants Reine Fabiola (HUDERF), Brussels, Belgium.
⁹ Department of Haemato-oncology, Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium.
¹⁰ Department of Paediatrics, Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium.
¹¹ Department of Haematology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
¹² Department of Haemato-oncolocy, Hôpital Erasme, Brussels, Belgium.
¹³ Department of Haematology, Guy's and St Thomas' NHS Foundation Trust, London, UK.
¹⁴ Department of Haematology, Hôpital de Jolimont, Haine-St-Paul, Belgium.
¹⁵ Department of Haemato-oncology, Centre Hospitalier Universitaire Brugmann, Brussels, Belgium.
¹⁶ Department of Haematology, Centre Hospitalier Universitaire de Liège, Liège, Belgium.
¹⁷ Clinical Research Unit, Academic Medical Centre, Amsterdam, the Netherlands.

PMID: 28643376
DOI: 10.1111/bjh.14809

No abstract available

Keywords: N-acetylcysteine; pain; randomised clinical trial; sickle cell disease; vaso-occlusive crisis.

Publication types

Letter
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Acetylcysteine / adverse effects
Acetylcysteine / pharmacology
Acetylcysteine / therapeutic use*
Adolescent
Adult
Anemia, Sickle Cell / drug therapy
Anemia, Sickle Cell / pathology*
Antioxidants
Child
Female
Humans
Male
Medication Adherence
Pain / prevention & control*
Treatment Outcome
Young Adult

Substances

Antioxidants
Acetylcysteine