Use of platelet-rich plasma (PRP) in microsurgery

B Hersant; S La Padula; M SidAhmed-Mezi; A M Rodriguez; J P Meningaud

doi:10.1016/j.jormas.2017.05.009

Use of platelet-rich plasma (PRP) in microsurgery

J Stomatol Oral Maxillofac Surg. 2017 Sep;118(4):236-237. doi: 10.1016/j.jormas.2017.05.009. Epub 2017 Jun 19.

Authors

B Hersant¹, S La Padula², M SidAhmed-Mezi¹, A M Rodriguez³, J P Meningaud¹

Affiliations

¹ Department of Maxillo-facial and Plastic and Reconstructive Surgery, Henri-Mondor hospital, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France.
² Department of Maxillo-facial and Plastic and Reconstructive Surgery, Henri-Mondor hospital, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France. Electronic address: drsimonelapadula@gmail.com.
³ Inserm U955, Team 12, université Paris Est, UMR-S955, UPEC, Créteil, France.

PMID: 28642184
DOI: 10.1016/j.jormas.2017.05.009

Abstract

Platelet-rich plasma (PRP) is currently used for its property to improve tissue regeneration and wound healing. Platelet derived growth factors are involved in tissue regeneration and new vessels formation that could improve a free flap survival. Nevertheless to validate the use of regenerative medicine in microsurgery further large and robust human clinical trials are needed.

Keywords: Flap; Microsurgery; Nerve regeneration; Platelet gel; Platelet-rich plasma; Stem cells.

Publication types

Review

MeSH terms

Cell Differentiation
Cell Proliferation
Free Tissue Flaps / transplantation
Humans
Mesenchymal Stem Cells / cytology
Mesenchymal Stem Cells / physiology
Microsurgery / methods*
Microsurgery / trends
Nerve Regeneration / physiology
Platelet-Rich Plasma / cytology
Platelet-Rich Plasma / physiology*
Regenerative Medicine / methods*
Skin / physiopathology
Skin Physiological Phenomena
Wound Healing / physiology