Abstract
A new bibenzyl derivative (4), together with two glycosylated flavonoids (1 and 2), batatasin III (3) and the phenanthrene isohircinol (5) were isolated from the aerial parts of Gavilea lutea. Their structures were elucidated on the basis of spectroscopic studies including 1D and 2D NMR, UV, IR and HRESIMS. All isolated compounds were evaluated for their antifungal activity towards Candida albicans. The new compound 4 showed inhibitory activity with a MIQ of 50 μg. In addition, compound 4 exhibited a selective activity (IC50 = 2.3 μg/mL) against Leishmania donovani.
Keywords:
Gavilea lutea; antifungal activity; antiprotozoal activity; bibenzyls; gavilein.
MeSH terms
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Animals
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology*
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Antiprotozoal Agents / chemistry
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Antiprotozoal Agents / pharmacology*
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Benzyl Compounds / chemistry
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Benzyl Compounds / pharmacology*
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Bibenzyls / chemistry*
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Candida albicans / drug effects
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Drug Evaluation, Preclinical / methods
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Flavonoids / chemistry
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Flavonoids / pharmacology
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Leishmania donovani / drug effects
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Orchidaceae / chemistry*
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Plant Components, Aerial / chemistry
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Rats
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Ultraviolet
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Stilbenes / isolation & purification
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Stilbenes / pharmacology
Substances
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Antifungal Agents
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Antiprotozoal Agents
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Benzyl Compounds
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Bibenzyls
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Flavonoids
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Stilbenes
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batatasin-III